Assay Detail
Functional
CHEMBL1107756
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Antiproliferative activity against mouse BAF3 cells expressing TEL-JAK3 kinase after 72 hrs by alamar blue assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.57 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078275 | — | — | 1 | 6.62 |
| CHEMBL1078364 | — | — | 1 | 6.56 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 6.24 |
| CHEMBL1078276 | — | — | 1 | 6.14 |
| CHEMBL1078720 | — | — | 1 | 5.96 |
| CHEMBL1078933 | — | — | 1 | 5.91 |
| CHEMBL1079121 | — | — | 1 | 5.77 |
| CHEMBL1078277 | — | — | 1 | 5.76 |
| CHEMBL1078688 | — | — | 1 | 5.71 |
| CHEMBL1078689 | — | — | 1 | 5.71 |
| CHEMBL1078934 | — | — | 1 | 5.69 |
| CHEMBL1078767 | — | — | 1 | 5.66 |
| CHEMBL1078178 | MOMELOTINIB | 4.0 | 1 | 5.62 |
| CHEMBL1078274 | — | — | 1 | 5.59 |
| CHEMBL1078866 | — | — | 1 | 5.50 |
| CHEMBL1078228 | — | — | 1 | 5.48 |
| CHEMBL1078971 | — | — | 1 | 5.46 |
| CHEMBL1078889 | — | — | 1 | 5.45 |
| CHEMBL1079077 | — | — | 1 | 5.40 |
| CHEMBL1078166 | — | — | 1 | 5.38 |
| CHEMBL1078453 | — | — | 1 | 5.37 |
| CHEMBL1078005 | — | — | 1 | 5.22 |
| CHEMBL1077841 | — | — | 1 | 5.20 |
| CHEMBL1079078 | — | — | 1 | 5.18 |
| CHEMBL1078229 | — | — | 1 | 5.13 |
| CHEMBL1078363 | — | — | 1 | 5.12 |
| CHEMBL1078721 | — | — | 1 | 5.02 |
| CHEMBL1077842 | — | — | 1 | 5.00 |
| CHEMBL1078370 | — | — | 1 | 4.77 |
| CHEMBL1079120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078275 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1078364 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1078276 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1078720 | — | IC50 | = | 1105.0 | nM | 5.96 |
| CHEMBL1078933 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL1079121 | — | IC50 | = | 1709.0 | nM | 5.77 |
| CHEMBL1078277 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL1078688 | — | IC50 | = | 1944.0 | nM | 5.71 |
| CHEMBL1078689 | — | IC50 | = | 1944.0 | nM | 5.71 |
| CHEMBL1078934 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL1078767 | — | IC50 | = | 2196.0 | nM | 5.66 |
| CHEMBL1078178 | MOMELOTINIB | IC50 | = | 2425.0 | nM | 5.62 |
| CHEMBL1078274 | — | IC50 | = | 2553.0 | nM | 5.59 |
| CHEMBL1078866 | — | IC50 | = | 3143.0 | nM | 5.50 |
| CHEMBL1078228 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL1078971 | — | IC50 | = | 3433.0 | nM | 5.46 |
| CHEMBL1078889 | — | IC50 | = | 3557.0 | nM | 5.45 |
| CHEMBL1079077 | — | IC50 | = | 3945.0 | nM | 5.40 |
| CHEMBL1078166 | — | IC50 | = | 4205.0 | nM | 5.38 |
| CHEMBL1078453 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL1078005 | — | IC50 | = | 5959.0 | nM | 5.22 |
| CHEMBL1077841 | — | IC50 | = | 6245.0 | nM | 5.20 |
| CHEMBL1079078 | — | IC50 | = | 6551.0 | nM | 5.18 |
| CHEMBL1078229 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL1078363 | — | IC50 | = | 7567.0 | nM | 5.12 |
| CHEMBL1078721 | — | IC50 | = | 9505.0 | nM | 5.02 |
| CHEMBL1077842 | — | IC50 | = | 9975.0 | nM | 5.00 |
| CHEMBL1078370 | — | IC50 | = | 16880.0 | nM | 4.77 |
| CHEMBL1079120 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1078165 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1077575 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1078159 | — | IC50 | > | 20000.0 | nM | - |