Assay Detail
Functional
CHEMBL1107773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NLBal infected JC53BL cells assessed as inhibition of replication by luciferase reporter assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | JC53BL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.62 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077363 | — | — | 1 | 8.40 |
| CHEMBL1078231 | — | — | 1 | 8.22 |
| CHEMBL1077359 | — | — | 1 | 8.05 |
| CHEMBL1077364 | — | — | 1 | 7.92 |
| CHEMBL1077365 | — | — | 1 | 7.92 |
| CHEMBL1077361 | — | — | 1 | 7.75 |
| CHEMBL1077362 | — | — | 1 | 7.72 |
| CHEMBL1077355 | — | — | 1 | 7.23 |
| CHEMBL1077358 | — | — | 1 | 6.58 |
| CHEMBL1077354 | — | — | 1 | 6.45 |
| CHEMBL1077350 | — | — | 1 | - |
| CHEMBL1077351 | — | — | 1 | - |
| CHEMBL1077352 | — | — | 1 | - |
| CHEMBL1077353 | — | — | 1 | - |
| CHEMBL1077360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077363 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1078231 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1077359 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1077364 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1077365 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1077361 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1077362 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1077355 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1077358 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL1077354 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL1077350 | — | IC50 | > | 625.0 | nM | - |
| CHEMBL1077351 | — | IC50 | > | 625.0 | nM | - |
| CHEMBL1077352 | — | IC50 | > | 625.0 | nM | - |
| CHEMBL1077353 | — | IC50 | > | 625.0 | nM | - |
| CHEMBL1077360 | — | IC50 | >= | 625.0 | nM | - |