Assay Detail
Functional
CHEMBL1107901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human LNCAP cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.73 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091492 | — | — | 1 | 9.00 |
| CHEMBL1093754 | — | — | 1 | 9.00 |
| CHEMBL1092781 | — | — | 1 | 9.00 |
| CHEMBL1090388 | — | — | 1 | 9.00 |
| CHEMBL1091491 | — | — | 1 | 9.00 |
| CHEMBL1090382 | — | — | 1 | 8.70 |
| CHEMBL1090381 | — | — | 1 | 8.70 |
| CHEMBL1090383 | — | — | 1 | 8.52 |
| CHEMBL1088745 | — | — | 1 | 8.40 |
| CHEMBL1092815 | — | — | 1 | 8.40 |
| CHEMBL1092768 | — | — | 1 | 8.30 |
| CHEMBL1092120 | — | — | 1 | 8.10 |
| CHEMBL1092485 | — | — | 1 | 8.05 |
| CHEMBL1094015 | — | — | 1 | 8.00 |
| CHEMBL1094016 | — | — | 1 | 7.12 |
| CHEMBL1091456 | — | — | 1 | 7.11 |
| CHEMBL1094017 | — | — | 1 | 6.96 |
| CHEMBL1090043 | — | — | 1 | 6.70 |
| CHEMBL1092474 | — | — | 1 | 6.62 |
| CHEMBL1088746 | — | — | 1 | 6.22 |
| CHEMBL1091071 | — | — | 1 | 5.85 |
| CHEMBL1092814 | — | — | 1 | 5.75 |
| CHEMBL1091455 | — | — | 1 | 5.19 |
| CHEMBL1092818 | — | — | 1 | - |
| CHEMBL1092486 | — | — | 1 | - |
| CHEMBL1092119 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091492 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1093754 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1092781 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1090388 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1091491 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1090382 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1090381 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1090383 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1088745 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1092815 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1092768 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1092120 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1092485 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1094015 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1094016 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1091456 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1094017 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1090043 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1092474 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1088746 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1091071 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1092814 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1091455 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1092818 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL1092486 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL1092119 | — | IC50 | < | 1.0 | nM | - |