Assay Detail
Functional
CHEMBL1107967
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Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting in presence of 10 uM allosteric modulator PD-81723
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hybrid ortho/allosteric ligands for the adenosine A(1) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.19 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093910 | — | — | 2 | 7.54 |
| CHEMBL1090683 | — | — | 2 | 7.29 |
| CHEMBL1090687 | — | — | 2 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093910 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1093910 | — | EC50 | = | 30.2 | nM | 7.52 |
| CHEMBL1090683 | — | EC50 | = | 51.29 | nM | 7.29 |
| CHEMBL1090683 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1090687 | — | EC50 | = | 177.83 | nM | 6.75 |
| CHEMBL1090687 | — | EC50 | = | 181.0 | nM | 6.74 |