Assay Detail
Functional
CHEMBL1107990
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4.3 infected in human PBMC assessed as inhibition of virus-induced cytopathicity
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 2 | - | - |
| IC50 | 2 | 7.31 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518924 | MAVORIXAFOR | 4.0 | 2 | 8.05 |
| CHEMBL1089434 | — | — | 1 | 6.56 |
| CHEMBL1093137 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518924 | MAVORIXAFOR | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1089434 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL1093137 | — | IC90 | = | 559.0 | nM | - |
| CHEMBL518924 | MAVORIXAFOR | IC90 | = | 26.0 | nM | - |