Assay Detail
ADMET
CHEMBL1107998
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Cytotoxicity against human MT4 cells expressing CD4 and CXCR4 assessed as cell viability
38
Total Activities
38
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| CC50 | 37 | - | - |
| IC50 | 1 | 6.97 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093149 | — | — | 1 | 6.97 |
| CHEMBL1092301 | — | — | 1 | - |
| CHEMBL1090513 | — | — | 1 | - |
| CHEMBL1093137 | — | — | 1 | - |
| CHEMBL1089434 | — | — | 1 | - |
| CHEMBL1089100 | — | — | 1 | - |
| CHEMBL1091557 | — | — | 1 | - |
| CHEMBL1091176 | — | — | 1 | - |
| CHEMBL1091175 | — | — | 1 | - |
| CHEMBL1091174 | — | — | 1 | - |
| CHEMBL1088858 | — | — | 1 | - |
| CHEMBL1090514 | — | — | 1 | - |
| CHEMBL1090509 | — | — | 1 | - |
| CHEMBL1092629 | — | — | 1 | - |
| CHEMBL1092628 | — | — | 1 | - |
| CHEMBL1092302 | — | — | 1 | - |
| CHEMBL1088916 | — | — | 1 | - |
| CHEMBL1092596 | — | — | 1 | - |
| CHEMBL1088913 | — | — | 1 | - |
| CHEMBL1088912 | — | — | 1 | - |
| CHEMBL1093302 | — | — | 1 | - |
| CHEMBL1089846 | — | — | 1 | - |
| CHEMBL1089845 | — | — | 1 | - |
| CHEMBL1089844 | — | — | 1 | - |
| CHEMBL1093008 | — | — | 1 | - |
| CHEMBL1088867 | — | — | 1 | - |
| CHEMBL1092324 | — | — | 1 | - |
| CHEMBL1092323 | — | — | 1 | - |
| CHEMBL1092905 | — | — | 1 | - |
| CHEMBL1092322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093149 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL1093137 | — | CC50 | = | 380.0 | nM | - |
| CHEMBL1090514 | — | CC50 | = | 44000.0 | nM | - |
| CHEMBL1088858 | — | CC50 | > | 118000.0 | nM | - |
| CHEMBL1091174 | — | CC50 | = | 21000.0 | nM | - |
| CHEMBL1091175 | — | CC50 | = | 500.0 | nM | - |
| CHEMBL1091176 | — | CC50 | = | 126000.0 | nM | - |
| CHEMBL1091557 | — | CC50 | = | 23000.0 | nM | - |
| CHEMBL1089100 | — | CC50 | = | 21000.0 | nM | - |
| CHEMBL1089434 | — | CC50 | = | 23000.0 | nM | - |
| CHEMBL1090509 | — | CC50 | = | 2470.0 | nM | - |
| CHEMBL1090513 | — | CC50 | = | 124000.0 | nM | - |
| CHEMBL1090510 | — | CC50 | = | 21000.0 | nM | - |
| CHEMBL1093455 | — | CC50 | = | 8000.0 | nM | - |
| CHEMBL1091201 | — | CC50 | = | 204000.0 | nM | - |
| CHEMBL1089868 | — | CC50 | = | 22300.0 | nM | - |
| CHEMBL1090194 | — | CC50 | = | 23100.0 | nM | - |
| CHEMBL1092252 | — | CC50 | = | 101000.0 | nM | - |
| CHEMBL1092253 | — | CC50 | = | 37500.0 | nM | - |
| CHEMBL1092254 | — | CC50 | = | 36800.0 | nM | - |
| CHEMBL1089846 | — | CC50 | = | 10800.0 | nM | - |
| CHEMBL1092322 | — | CC50 | = | 34300.0 | nM | - |
| CHEMBL1092905 | — | CC50 | = | 26400.0 | nM | - |
| CHEMBL1092323 | — | CC50 | = | 126800.0 | nM | - |
| CHEMBL1092324 | — | CC50 | = | 238000.0 | nM | - |
| CHEMBL1088867 | — | CC50 | = | 45900.0 | nM | - |
| CHEMBL1093008 | — | CC50 | = | 29600.0 | nM | - |
| CHEMBL1089844 | — | CC50 | = | 51900.0 | nM | - |
| CHEMBL1089845 | — | CC50 | = | 50800.0 | nM | - |
| CHEMBL1092629 | — | CC50 | = | 152000.0 | nM | - |
| CHEMBL1093302 | — | CC50 | = | 6860.0 | nM | - |
| CHEMBL1088912 | — | CC50 | = | 32900.0 | nM | - |
| CHEMBL1088913 | — | CC50 | = | 160000.0 | nM | - |
| CHEMBL1092596 | — | CC50 | = | 30200.0 | nM | - |
| CHEMBL1088916 | — | CC50 | = | 30200.0 | nM | - |
| CHEMBL1092301 | — | CC50 | = | 29500.0 | nM | - |
| CHEMBL1092302 | — | CC50 | = | 28200.0 | nM | - |
| CHEMBL1092628 | — | CC50 | = | 55300.0 | nM | - |