Assay Detail
Binding
CHEMBL1108113
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Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.35 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225155 | — | — | 1 | 9.04 |
| CHEMBL514170 | — | — | 1 | 7.70 |
| CHEMBL475405 | — | — | 1 | 6.70 |
| CHEMBL1088820 | — | — | 1 | 6.54 |
| CHEMBL1090828 | — | — | 1 | 6.16 |
| CHEMBL1089127 | — | — | 1 | 6.00 |
| CHEMBL1088819 | — | — | 1 | 5.70 |
| CHEMBL1093823 | — | — | 1 | 5.70 |
| CHEMBL1093424 | — | — | 1 | 5.49 |
| CHEMBL1090796 | — | — | 1 | 5.42 |
| CHEMBL1093429 | — | — | 1 | 5.35 |
| CHEMBL1092190 | — | — | 1 | - |
| CHEMBL1092191 | — | — | 1 | - |
| CHEMBL1090673 | — | — | 1 | - |
| CHEMBL1090782 | — | — | 1 | - |
| CHEMBL1090829 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225155 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL514170 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL475405 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1088820 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL1090828 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1089127 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1088819 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1093823 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1093424 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL1090796 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1093429 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1092190 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1092191 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1090673 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1090782 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1090829 | — | IC50 | > | 100000.0 | nM | - |