Assay Detail
Binding
CHEMBL1108114
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Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.31 | 8.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225155 | — | — | 1 | 8.98 |
| CHEMBL1093429 | — | — | 1 | 8.47 |
| CHEMBL1093823 | — | — | 1 | 8.36 |
| CHEMBL514170 | — | — | 1 | 8.31 |
| CHEMBL1090829 | — | — | 1 | 8.19 |
| CHEMBL475405 | — | — | 1 | 7.99 |
| CHEMBL1090796 | — | — | 1 | 7.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225155 | — | IC50 | = | 1.04 | nM | 8.98 |
| CHEMBL1093429 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1093823 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL514170 | — | IC50 | = | 4.87 | nM | 8.31 |
| CHEMBL1090829 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL475405 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL1090796 | — | IC50 | = | 13.1 | nM | 7.88 |