Assay Detail
Binding
CHEMBL1108129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human recombinant GluA4 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM staining-based fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.05 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097939 | — | — | 1 | 6.68 |
| CHEMBL61593 | CYCLOTHIAZIDE | 4.0 | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097939 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL61593 | CYCLOTHIAZIDE | EC50 | = | 3910.0 | nM | 5.41 |