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Compound Detail

CHEMBL1097939

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CC(CNS(=O)(=O)C(C)C)C1CCC(c2ccc(C#N)cc2)CC1

Basic Information

ChEMBL ID CHEMBL1097939
Phase Preclinical
Structure Type MOL
InChI Key AIALBPYHYGYYRB-UHFFFAOYSA-N
4
Targets
7
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

348.5
MW (Da)
3.80
ALogP
3
HBA
1
HBD
70.0
PSA (Ų)
0.85
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H28N2O2S
MW 348.51
Aromatic Rings 1
Heavy Atoms 24
NP-Likeness -0.88

Activity Summary

EC50 7 meas. best 6.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Glutamate receptor 2
CHEMBL4016
EC50 6.82 5.83 150.0 4
Unchecked
CHEMBL612545
EC50 6.68 6.68 210.0 1
Glutamate receptor 3
CHEMBL3595
EC50 5.78 5.78 1660.0 1
Glutamate receptor 1
CHEMBL2009
EC50 5.25 5.25 5650.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20096591 10.1016/j.bmc.2009.12.072 Glutamate receptor 2 4
20096591 10.1016/j.bmc.2009.12.072 Unchecked 2
20096591 10.1016/j.bmc.2009.12.072 Glutamate receptor 1 1
20096591 10.1016/j.bmc.2009.12.072 Glutamate receptor 3 1

Data from ChEMBL 36 via Core Engine