Assay Detail
Binding
CHEMBL1108193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of serotonin 5-HT1A receptor partial agonists in ginger.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.12 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1094100 | — | — | 1 | 5.45 |
| CHEMBL549472 | — | — | 1 | 5.43 |
| CHEMBL24226 | — | — | 1 | 5.23 |
| CHEMBL1096044 | — | — | 1 | 5.18 |
| CHEMBL555195 | — | — | 1 | 5.18 |
| CHEMBL1094101 | — | — | 1 | 5.02 |
| CHEMBL1095671 | — | — | 1 | 4.93 |
| CHEMBL25893 | — | — | 1 | 4.88 |
| CHEMBL25948 | SHOGAOL | — | 1 | 4.74 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | - |
| CHEMBL402978 | GINGEROL | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1094100 | — | Ki | = | 3590.0 | nM | 5.45 |
| CHEMBL549472 | — | Ki | = | 3740.0 | nM | 5.43 |
| CHEMBL24226 | — | Ki | = | 5840.0 | nM | 5.23 |
| CHEMBL1096044 | — | Ki | = | 6540.0 | nM | 5.18 |
| CHEMBL555195 | — | Ki | = | 6530.0 | nM | 5.18 |
| CHEMBL1094101 | — | Ki | = | 9530.0 | nM | 5.02 |
| CHEMBL1095671 | — | Ki | = | 11710.0 | nM | 4.93 |
| CHEMBL25893 | — | Ki | = | 13050.0 | nM | 4.88 |
| CHEMBL25948 | SHOGAOL | Ki | = | 18020.0 | nM | 4.74 |
| CHEMBL39 | SEROTONIN | Ki | < | 50.0 | nM | - |
| CHEMBL402978 | GINGEROL | Ki | > | 100000.0 | nM | - |