Assay Detail
Functional
CHEMBL1108790
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Antiproliferative activity against human LNCAP cells
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Arylureidophenyl-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines as highly potent and selective ATP competitive mTOR inhibitors: optimization of human microsomal stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.25 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091350 | — | — | 1 | 9.10 |
| CHEMBL1092397 | — | — | 1 | 9.10 |
| CHEMBL1092396 | — | — | 1 | 9.10 |
| CHEMBL1092398 | — | — | 1 | 9.10 |
| CHEMBL1091356 | — | — | 1 | 9.05 |
| CHEMBL1076864 | — | — | 1 | 9.00 |
| CHEMBL1091354 | — | — | 1 | 9.00 |
| CHEMBL1088973 | — | — | 1 | 8.89 |
| CHEMBL1092394 | — | — | 1 | 8.52 |
| CHEMBL1092395 | — | — | 1 | 8.52 |
| CHEMBL1092392 | — | — | 1 | 8.40 |
| CHEMBL1092393 | — | — | 1 | 8.30 |
| CHEMBL1091711 | — | — | 1 | 8.22 |
| CHEMBL1091348 | — | — | 1 | 8.22 |
| CHEMBL1091712 | — | — | 1 | 8.10 |
| CHEMBL1091359 | — | — | 1 | 8.05 |
| CHEMBL1091715 | — | — | 1 | 7.92 |
| CHEMBL1091353 | — | — | 1 | 7.75 |
| CHEMBL1091351 | — | — | 1 | 7.70 |
| CHEMBL1091349 | — | — | 1 | 7.60 |
| CHEMBL1091345 | — | — | 1 | 7.30 |
| CHEMBL1091346 | — | — | 1 | 6.62 |
| CHEMBL1091347 | — | — | 1 | 6.10 |
| CHEMBL1091352 | — | — | 1 | - |
| CHEMBL1091355 | — | — | 1 | - |
| CHEMBL1091357 | — | — | 1 | - |
| CHEMBL1091358 | — | — | 1 | - |
| CHEMBL1091360 | — | — | 1 | - |
| CHEMBL1091344 | — | — | 1 | - |
| CHEMBL1091596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091350 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1092398 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1092396 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1092397 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1091356 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1076864 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1091354 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1088973 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1092394 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1092395 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1092392 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1092393 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1091711 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1091348 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1091712 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1091359 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1091715 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1091353 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1091351 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1091349 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1091345 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1091346 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1091347 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1092391 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1091714 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1092389 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1091713 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1092390 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1091596 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1091344 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1091360 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1091358 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1091357 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1091355 | — | IC50 | < | 0.8 | nM | - |
| CHEMBL1091352 | — | IC50 | < | 0.8 | nM | - |