Assay Detail
Binding
CHEMBL1108832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant IGF1R expressed in Sf21 cells by time resolved fluorescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.56 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090364 | — | — | 1 | 7.57 |
| CHEMBL1090363 | — | — | 1 | 7.34 |
| CHEMBL1090362 | — | — | 1 | 7.28 |
| CHEMBL1090361 | — | — | 1 | 7.09 |
| CHEMBL1090359 | — | — | 1 | 7.00 |
| CHEMBL1090356 | — | — | 1 | 6.89 |
| CHEMBL1090357 | — | — | 1 | 6.68 |
| CHEMBL1090358 | — | — | 1 | 6.64 |
| CHEMBL1090360 | — | — | 1 | 6.55 |
| CHEMBL1090355 | — | — | 1 | 6.35 |
| CHEMBL1090353 | — | — | 1 | 6.24 |
| CHEMBL1090354 | — | — | 1 | 6.23 |
| CHEMBL1090352 | — | — | 1 | 5.96 |
| CHEMBL1090351 | — | — | 1 | 5.89 |
| CHEMBL1090350 | — | — | 1 | 5.82 |
| CHEMBL1088931 | — | — | 1 | 5.42 |
| CHEMBL1093486 | — | — | 1 | - |
| CHEMBL1093235 | — | — | 1 | - |
| CHEMBL1093234 | — | — | 1 | - |
| CHEMBL1093815 | — | — | 1 | - |
| CHEMBL1091613 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090364 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1090363 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1090362 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1090361 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1090359 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1090356 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1090357 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1090358 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1090360 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1090355 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1090353 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1090354 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1090352 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1090351 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1090350 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1088931 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1093486 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL1093235 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL1093234 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL1093815 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL1091613 | — | IC50 | > | 12500.0 | nM | - |