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Assay Detail

CHEMBL1109003

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Vibrio cholerae neuraminidase assessed as inhibition of 4-MU-NANA hydrolysis after 30 mins by spectrofluorimetry
32
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Vibrio cholerae
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Sialidase (CHEMBL1075100)
Type SINGLE PROTEIN
Organism Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

Publication

Prenylated pterocarpans as bacterial neuraminidase inhibitors.
Nguyen PH, Nguyen TN, Kang KW, Ndinteh DT, Mbafor JT, Kim YR, Oh WK.
Bioorg Med Chem (2010) 18 : 3335 -3344
PubMed 20363636 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.73 6.46
Activity 16 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1096406 ERYTHRIBYSSIN O 2 6.46
CHEMBL1097045 ERYVARIN D 2 5.48
CHEMBL1096407 CALOPOCARPIN 2 5.12
CHEMBL1088321 SOPHORAPTEROCARPAN A 2 4.94
CHEMBL1086764 ERYSUBIN E 2 4.71
CHEMBL454849 ERYTHRABYSSIN I 2 4.66
CHEMBL1095422 ERYSUBIN D 2 4.58
CHEMBL1096408 ERYTHRIBYSSIN L 2 4.57
CHEMBL1088462 ERYSTAGALLIN A 2 4.56
CHEMBL1098413 DEMETHYLMEDICARPIN 2 4.53
CHEMBL448350 PHASEOLIN 2 4.50
CHEMBL1099089 ERYTHRIBYSSIN D 2 4.33
CHEMBL1098728 NEORAUTENOL 2 4.28
CHEMBL1098729 ISONEORAUTENOL 2 4.19
CHEMBL1099090 ERYTHRIBYSSIN M 2 4.11
CHEMBL50 QUERCETIN 3.0 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1096406 ERYTHRIBYSSIN O IC50 = 350.0 nM 6.46
CHEMBL1097045 ERYVARIN D IC50 = 3300.0 nM 5.48
CHEMBL1096407 CALOPOCARPIN IC50 = 7550.0 nM 5.12
CHEMBL1088321 SOPHORAPTEROCARPAN A IC50 = 11590.0 nM 4.94
CHEMBL1086764 ERYSUBIN E IC50 = 19480.0 nM 4.71
CHEMBL454849 ERYTHRABYSSIN I IC50 = 22030.0 nM 4.66
CHEMBL1095422 ERYSUBIN D IC50 = 26390.0 nM 4.58
CHEMBL1096408 ERYTHRIBYSSIN L IC50 = 27140.0 nM 4.57
CHEMBL1088462 ERYSTAGALLIN A IC50 = 27740.0 nM 4.56
CHEMBL1098413 DEMETHYLMEDICARPIN IC50 = 29540.0 nM 4.53
CHEMBL448350 PHASEOLIN IC50 = 31400.0 nM 4.50
CHEMBL1099089 ERYTHRIBYSSIN D IC50 = 46200.0 nM 4.33
CHEMBL1098728 NEORAUTENOL IC50 = 53110.0 nM 4.28
CHEMBL1098729 ISONEORAUTENOL IC50 = 64750.0 nM 4.19
CHEMBL1099090 ERYTHRIBYSSIN M IC50 = 77730.0 nM 4.11
CHEMBL50 QUERCETIN IC50 - -
CHEMBL1098413 DEMETHYLMEDICARPIN Activity - -
CHEMBL1098728 NEORAUTENOL Activity - -
CHEMBL1098729 ISONEORAUTENOL Activity - -
CHEMBL448350 PHASEOLIN Activity - -
CHEMBL1097045 ERYVARIN D Activity - -
CHEMBL1096406 ERYTHRIBYSSIN O Activity - -
CHEMBL1096407 CALOPOCARPIN Activity - -
CHEMBL1096408 ERYTHRIBYSSIN L Activity - -
CHEMBL1095422 ERYSUBIN D Activity - -
CHEMBL1086764 ERYSUBIN E Activity - -
CHEMBL1099089 ERYTHRIBYSSIN D Activity - -
CHEMBL1099090 ERYTHRIBYSSIN M Activity - -
CHEMBL454849 ERYTHRABYSSIN I Activity - -
CHEMBL1088321 SOPHORAPTEROCARPAN A Activity - -
CHEMBL1088462 ERYSTAGALLIN A Activity - -
CHEMBL50 QUERCETIN Activity - -