Assay Detail
Functional
CHEMBL1109709
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Antiproliferative activity against human MCF7.1 cells after 3 days by celltiter-glo luminescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7.1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.08 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090601 | — | — | 1 | 10.40 |
| CHEMBL1090598 | — | — | 1 | 9.77 |
| CHEMBL1090599 | — | — | 1 | 9.72 |
| CHEMBL1090600 | — | — | 1 | 9.54 |
| CHEMBL594844 | — | — | 1 | 9.37 |
| CHEMBL1093267 | — | — | 1 | 7.19 |
| CHEMBL1091977 | — | — | 1 | 7.17 |
| CHEMBL1090239 | — | — | 1 | 7.11 |
| CHEMBL1083192 | — | — | 1 | 6.89 |
| CHEMBL1091978 | — | — | 1 | 6.84 |
| CHEMBL1091979 | — | — | 1 | 6.79 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090601 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL1090598 | — | EC50 | = | 0.17 | nM | 9.77 |
| CHEMBL1090599 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL1090600 | — | EC50 | = | 0.29 | nM | 9.54 |
| CHEMBL594844 | — | EC50 | = | 0.43 | nM | 9.37 |
| CHEMBL1093267 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1091977 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1090239 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1083192 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1091978 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL1091979 | — | EC50 | = | 164.0 | nM | 6.79 |
| CHEMBL521851 | PICTILISIB | EC50 | = | 720.0 | nM | 6.14 |