Assay Detail
Binding
CHEMBL1109910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Trypanosoma brucei brucei recombinant rhodesain after 5 mins by spectrofluorimetry
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei brucei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.22 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261657 | THIOSEMICARBAZONE STANDARD | — | 1 | 7.36 |
| CHEMBL1089482 | FUMITREMORGIN B | — | 1 | 5.07 |
| CHEMBL2367464 | — | — | 1 | 4.96 |
| CHEMBL1089088 | — | — | 1 | 4.89 |
| CHEMBL1088849 | DEHYDROBIS(METHYLTHIO)GLIOTOXIN | — | 1 | 4.71 |
| CHEMBL463268 | VERRUCULOGEN | — | 1 | 4.35 |
| CHEMBL1089086 | DIACETYLBIS(METHYLTHIO)GLIOTOXIN | — | 1 | - |
| CHEMBL1089087 | — | — | 1 | - |
| CHEMBL512683 | CHETOSEMINUDIN B | — | 1 | - |
| CHEMBL1089314 | 3,6 BISMETHYL(THIOCYCLO)ALANYLTRYPTOPHYL | — | 1 | - |
| CHEMBL331627 | GLIOTOXIN | — | 1 | - |
| CHEMBL1089315 | VERTICILLIN B | — | 1 | - |
| CHEMBL1089316 | CHAETOCIN | — | 1 | - |
| CHEMBL488302 | SPIROTRYPROSTATIN B | — | 1 | - |
| CHEMBL549475 | SPIROTRYPROSTATIN A | — | 1 | - |
| CHEMBL1089800 | N-METHYL-6-METHOXYSPIROTRYPROSTATIN B | — | 1 | - |
| CHEMBL1089801 | N-METHYLSPIROTRYPROSTATIN A | — | 1 | - |
| CHEMBL1090129 | VERRUCULOGEN TR-2 | — | 1 | - |
| CHEMBL1089971 | CYCLOTRYPROSTATIN A | — | 1 | - |
| CHEMBL254412 | — | — | 1 | - |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | - |
| CHEMBL1088981 | BIS(DETHIO)BIS(METHYLTHIO)GLIOTOXIN | — | 1 | - |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261657 | THIOSEMICARBAZONE STANDARD | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1089482 | FUMITREMORGIN B | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2367464 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL1089088 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL1088849 | DEHYDROBIS(METHYLTHIO)GLIOTOXIN | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL463268 | VERRUCULOGEN | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1089086 | DIACETYLBIS(METHYLTHIO)GLIOTOXIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL1089087 | — | IC50 | - | — | - | |
| CHEMBL512683 | CHETOSEMINUDIN B | IC50 | > | 50000.0 | nM | - |
| CHEMBL1089314 | 3,6 BISMETHYL(THIOCYCLO)ALANYLTRYPTOPHYL | IC50 | - | — | - | |
| CHEMBL331627 | GLIOTOXIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL1089315 | VERTICILLIN B | IC50 | > | 50000.0 | nM | - |
| CHEMBL1089316 | CHAETOCIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL488302 | SPIROTRYPROSTATIN B | IC50 | > | 50000.0 | nM | - |
| CHEMBL549475 | SPIROTRYPROSTATIN A | IC50 | - | — | - | |
| CHEMBL1089800 | N-METHYL-6-METHOXYSPIROTRYPROSTATIN B | IC50 | - | — | - | |
| CHEMBL1089801 | N-METHYLSPIROTRYPROSTATIN A | IC50 | - | — | - | |
| CHEMBL1090129 | VERRUCULOGEN TR-2 | IC50 | - | — | - | |
| CHEMBL1089971 | CYCLOTRYPROSTATIN A | IC50 | - | — | - | |
| CHEMBL254412 | — | IC50 | - | — | - | |
| CHEMBL55 | PENTAMIDINE | IC50 | - | — | - | |
| CHEMBL1088981 | BIS(DETHIO)BIS(METHYLTHIO)GLIOTOXIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL166 | MELARSOPROL | IC50 | - | — | - |