Compound Detail
CHEMBL254412
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Basic Information
| ChEMBL ID | CHEMBL254412 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BDSGZPUKZJAYIB-UHFFFAOYSA-N |
7
Targets
8
Activities
2
Assay Types
2
PK Parameters
17
Publications
0
Known Names
Molecular Properties
377.2
MW (Da)
3.00
ALogP
7
HBA
2
HBD
99.7
PSA (Ų)
0.69
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.96
EC50 3 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei CHEMBL612849 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
| Trypanosoma brucei brucei CHEMBL612851 | EC50 | 6.96 | 6.96 | 110.0 | 1 |
| Cathepsin B-like cysteine protease CHEMBL5832 | IC50 | 6.57 | 6.57 | 270.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.57 | 6.57 | 270.0 | 1 |
| Procathepsin L CHEMBL3837 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Trypanosoma brucei CHEMBL612849 | EC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Cathepsin B CHEMBL4072 | IC50 | 5.26 | 5.26 | 5430.0 | 1 |
| HEK293 CHEMBL614818 | EC50 | 4.6 | 4.6 | 25000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 5.1 | hr | Mus musculus |
| T1/2 | 0.6 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei brucei | EC50 | = | 110.0 | nM | 6.96 | Antitrypanosomal activity against Trypanosoma brucei brucei 427-221a after 40 hr... | 20303767 |
| Trypanosoma brucei | IC50 | = | 110.0 | nM | 6.96 | Antitrypanosomal activity against Trypanosoma brucei | 18173229 |
| Cathepsin B-like cysteine protease | IC50 | = | 270.0 | nM | 6.57 | Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease | 18173229 |
| Unchecked | IC50 | = | 270.0 | nM | 6.57 | Inhibition of Trypanosoma brucei brucei recombinant cathepsin B assessed after 5... | 20303767 |
| Procathepsin L | IC50 | = | 300.0 | nM | 6.52 | Inhibition of human liver cathepsin L | 18173229 |
| Trypanosoma brucei | EC50 | = | 1400.0 | nM | 5.85 | Antitrypanosomal activity against Trypanosoma brucei after 48 hrs | 21051236 |
| Cathepsin B | IC50 | = | 5430.0 | nM | 5.26 | Inhibition of human liver cathepsin B | 18173229 |
| HEK293 | EC50 | = | 25000.0 | nM | 4.6 | Cytotoxicity against HEK293 cells | 20303767 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21051236 | 10.1016/j.bmc.2010.09.073 | No relevant target | 7 |
| 21051236 | 10.1016/j.bmc.2010.09.073 | ADMET | 6 |
| 21051236 | 10.1016/j.bmc.2010.09.073 | Mus musculus | 5 |
| 20303767 | 10.1016/j.bmc.2010.02.034 | Unchecked | 2 |
| 21051236 | 10.1016/j.bmc.2010.09.073 | HEK293 | 1 |
| 18173229 | 10.1021/jm070760l | Cathepsin B-like cysteine protease | 1 |
| 21051236 | 10.1016/j.bmc.2010.09.073 | HepG2 | 1 |
| 21051236 | 10.1016/j.bmc.2010.09.073 | BJ | 1 |
| 21051236 | 10.1016/j.bmc.2010.09.073 | Raji | 1 |
| 21051236 | 10.1016/j.bmc.2010.09.073 | Plasma | 1 |
| 21051236 | 10.1016/j.bmc.2010.09.073 | Trypanosoma brucei | 1 |
| 20303767 | 10.1016/j.bmc.2010.02.034 | HEK293 | 1 |
| 20303767 | 10.1016/j.bmc.2010.02.034 | Rhodesain | 1 |
| 20303767 | 10.1016/j.bmc.2010.02.034 | Trypanosoma brucei brucei | 1 |
| 18173229 | 10.1021/jm070760l | Cathepsin B | 1 |
| 18173229 | 10.1021/jm070760l | Procathepsin L | 1 |
| 18173229 | 10.1021/jm070760l | Trypanosoma brucei | 1 |
Data from ChEMBL 36 via Core Engine