Assay Detail
Functional
CHEMBL1109909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei 427-221a after 40 hrs by bioluminescence assay
24
Total Activities
24
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.13 | 8.70 |
| EC50 | 2 | 6.43 | 6.96 |
| IC100 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089316 | CHAETOCIN | — | 1 | 8.70 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.40 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.15 |
| CHEMBL1089315 | VERTICILLIN B | — | 1 | 8.15 |
| CHEMBL331627 | GLIOTOXIN | — | 1 | 8.00 |
| CHEMBL254412 | — | — | 1 | 6.96 |
| CHEMBL261657 | THIOSEMICARBAZONE STANDARD | — | 1 | 5.89 |
| CHEMBL488302 | SPIROTRYPROSTATIN B | — | 1 | 5.24 |
| CHEMBL512683 | CHETOSEMINUDIN B | — | 1 | 5.23 |
| CHEMBL2367464 | — | — | 1 | 5.19 |
| CHEMBL1089088 | — | — | 1 | 5.19 |
| CHEMBL1088849 | DEHYDROBIS(METHYLTHIO)GLIOTOXIN | — | 1 | 5.07 |
| CHEMBL463268 | VERRUCULOGEN | — | 1 | 4.89 |
| CHEMBL1089482 | FUMITREMORGIN B | — | 1 | 4.71 |
| CHEMBL1089086 | DIACETYLBIS(METHYLTHIO)GLIOTOXIN | — | 1 | 4.45 |
| CHEMBL1088981 | BIS(DETHIO)BIS(METHYLTHIO)GLIOTOXIN | — | 1 | 4.40 |
| CHEMBL1089971 | CYCLOTRYPROSTATIN A | — | 1 | - |
| CHEMBL133046 | ASCOFURANONE | — | 1 | - |
| CHEMBL1090129 | VERRUCULOGEN TR-2 | — | 1 | - |
| CHEMBL1089801 | N-METHYLSPIROTRYPROSTATIN A | — | 1 | - |
| CHEMBL1089800 | N-METHYL-6-METHOXYSPIROTRYPROSTATIN B | — | 1 | - |
| CHEMBL549475 | SPIROTRYPROSTATIN A | — | 1 | - |
| CHEMBL1089314 | 3,6 BISMETHYL(THIOCYCLO)ALANYLTRYPTOPHYL | — | 1 | - |
| CHEMBL1089087 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089316 | CHAETOCIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1089315 | VERTICILLIN B | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL331627 | GLIOTOXIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL254412 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL261657 | THIOSEMICARBAZONE STANDARD | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL488302 | SPIROTRYPROSTATIN B | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL512683 | CHETOSEMINUDIN B | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2367464 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1089088 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1088849 | DEHYDROBIS(METHYLTHIO)GLIOTOXIN | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL463268 | VERRUCULOGEN | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL1089482 | FUMITREMORGIN B | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL1089086 | DIACETYLBIS(METHYLTHIO)GLIOTOXIN | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL1088981 | BIS(DETHIO)BIS(METHYLTHIO)GLIOTOXIN | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL1089971 | CYCLOTRYPROSTATIN A | IC50 | > | 50000.0 | nM | - |
| CHEMBL133046 | ASCOFURANONE | IC100 | = | 0.03 | uM | - |
| CHEMBL1090129 | VERRUCULOGEN TR-2 | IC50 | > | 50000.0 | nM | - |
| CHEMBL1089801 | N-METHYLSPIROTRYPROSTATIN A | IC50 | > | 50000.0 | nM | - |
| CHEMBL1089800 | N-METHYL-6-METHOXYSPIROTRYPROSTATIN B | IC50 | > | 50000.0 | nM | - |
| CHEMBL549475 | SPIROTRYPROSTATIN A | IC50 | > | 50000.0 | nM | - |
| CHEMBL1089314 | 3,6 BISMETHYL(THIOCYCLO)ALANYLTRYPTOPHYL | IC50 | > | 50000.0 | nM | - |
| CHEMBL1089087 | — | IC50 | > | 50000.0 | nM | - |