Assay Detail
Binding
CHEMBL926730
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Inhibition of human liver cathepsin L
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 5.34 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL400663 | — | — | 1 | 6.52 |
| CHEMBL254412 | — | — | 1 | 6.52 |
| CHEMBL254617 | — | — | 1 | 6.38 |
| CHEMBL254619 | — | — | 1 | 6.30 |
| CHEMBL252934 | — | — | 1 | 6.21 |
| CHEMBL254618 | — | — | 1 | 6.11 |
| CHEMBL400542 | — | — | 1 | 6.10 |
| CHEMBL400543 | — | — | 1 | 6.06 |
| CHEMBL255087 | — | — | 1 | 5.93 |
| CHEMBL255038 | — | — | 1 | 5.74 |
| CHEMBL400095 | — | — | 1 | 5.64 |
| CHEMBL400097 | — | — | 1 | 5.64 |
| CHEMBL254227 | — | — | 1 | 5.62 |
| CHEMBL402052 | — | — | 1 | 5.60 |
| CHEMBL252360 | — | — | 1 | 5.48 |
| CHEMBL399094 | — | — | 1 | 5.42 |
| CHEMBL252363 | — | — | 1 | 5.41 |
| CHEMBL252362 | — | — | 1 | 5.40 |
| CHEMBL398505 | — | — | 1 | 5.38 |
| CHEMBL255079 | — | — | 1 | 5.36 |
| CHEMBL255080 | — | — | 1 | 5.30 |
| CHEMBL252359 | — | — | 1 | 5.23 |
| CHEMBL400096 | — | — | 1 | 5.23 |
| CHEMBL399027 | — | — | 1 | 5.17 |
| CHEMBL252729 | — | — | 1 | 5.17 |
| CHEMBL255086 | — | — | 1 | 5.09 |
| CHEMBL252158 | — | — | 1 | 5.03 |
| CHEMBL254827 | — | — | 1 | 5.02 |
| CHEMBL398311 | — | — | 1 | 4.98 |
| CHEMBL400248 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL400663 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL254412 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL254617 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL254619 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL252934 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL254618 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL400542 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL400543 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL255087 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL255038 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL400095 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL400097 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL254227 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL402052 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL252360 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL399094 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL252363 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL252362 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL398505 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL255079 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL255080 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL252359 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL400096 | — | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL399027 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL252729 | — | IC50 | = | 6680.0 | nM | 5.17 |
| CHEMBL255086 | — | IC50 | = | 8050.0 | nM | 5.09 |
| CHEMBL252158 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL254827 | — | IC50 | = | 9620.0 | nM | 5.02 |
| CHEMBL398311 | — | IC50 | = | 10520.0 | nM | 4.98 |
| CHEMBL400248 | — | IC50 | = | 10520.0 | nM | 4.98 |
| CHEMBL429121 | — | IC50 | = | 10790.0 | nM | 4.97 |
| CHEMBL252361 | — | IC50 | = | 11780.0 | nM | 4.93 |
| CHEMBL400454 | — | IC50 | = | 12220.0 | nM | 4.91 |
| CHEMBL251973 | — | IC50 | = | 12940.0 | nM | 4.89 |
| CHEMBL253611 | — | IC50 | = | 13550.0 | nM | 4.87 |
| CHEMBL400453 | — | IC50 | = | 13370.0 | nM | 4.87 |
| CHEMBL251923 | — | IC50 | = | 13550.0 | nM | 4.87 |
| CHEMBL400664 | — | IC50 | = | 14860.0 | nM | 4.83 |
| CHEMBL253830 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL398708 | — | IC50 | = | 17140.0 | nM | 4.77 |
| CHEMBL251959 | — | IC50 | = | 23280.0 | nM | 4.63 |
| CHEMBL399026 | — | IC50 | = | 26920.0 | nM | 4.57 |
| CHEMBL252156 | — | IC50 | = | 28440.0 | nM | 4.55 |
| CHEMBL436637 | — | IC50 | = | 28910.0 | nM | 4.54 |
| CHEMBL399095 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL252157 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL398507 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL399513 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL252558 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL400522 | — | IC50 | > | 30000.0 | nM | - |