Cathepsin B-like cysteine protease · SINGLE PROTEIN · Trypanosoma brucei
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As of 2026-09-14Protein identity stays anchored to UniProt Q6R7Z5. Use UniProt Q6R7Z5 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6R7Z5 as the stable identity anchor, then attach disease evidence before program review.
Cathepsin B-like cysteine protease
Review this target as Cathepsin B-like cysteine protease, mapped to UniProt Q6R7Z5. Sequence length is 340 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cathepsin B-like cysteine protease as ChEMBL target CHEMBL5832, mapped to UniProt Q6R7Z5. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cathepsin B-like cysteine protease |
| Target Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei |
| UniProt | Q6R7Z5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cathepsin B-like cysteine protease |
| UniProt Accession | Q6R7Z5 |
| Component Type | Protein |
| Sequence Length | 340 aa |
Cathepsin B-like cysteine protease
Review this target as Cathepsin B-like cysteine protease, mapped to UniProt Q6R7Z5. Sequence length is 340 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL254412 | 6.57 | IC50 | 270.0 | Preclinical |
| CHEMBL252934 | 6.24 | IC50 | 570.0 | Preclinical |
| CHEMBL400543 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL400542 | 6.03 | IC50 | 930.0 | Preclinical |
| CHEMBL254617 | 5.92 | IC50 | 1200.0 | Preclinical |
| CHEMBL400663 | 5.85 | IC50 | 1400.0 | Preclinical |
| CHEMBL399094 | 5.64 | IC50 | 2300.0 | Preclinical |
| CHEMBL254618 | 5.6 | IC50 | 2500.0 | Preclinical |
| CHEMBL252933 | 5.55 | IC50 | 2800.0 | Preclinical |
| CHEMBL251923 | 5.48 | IC50 | 3300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 60 | 4.9 |