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Assay Detail

CHEMBL1109941

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Functional
Antiviral activity against HIV1 infected in human MT4 cells assessed as protection against virus-induced cytopathic effect
ChEMBL ↗
77
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Support vector machines: development of QSAR models for predicting anti-HIV-1 activity of TIBO derivatives.
Darnag R, Mostapha Mazouz EL, Schmitzer A, Villemin D, Jarid A, Cherqaoui D.
Eur J Med Chem (2010) 45 : 1590 -1597
PubMed 20110136 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 77 5.92 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL354989 — — 1 8.52
CHEMBL58711 TIVIRAPINE 2.0 1 8.37
CHEMBL351433 — — 1 8.30
CHEMBL58119 — — 1 8.24
CHEMBL66155 — — 1 7.92
CHEMBL59279 — — 1 7.87
CHEMBL304294 — — 1 7.64
CHEMBL293814 — — 1 7.60
CHEMBL59131 — — 1 7.60
CHEMBL58811 — — 1 7.53
CHEMBL293498 — — 1 7.47
CHEMBL433931 — — 1 7.47
CHEMBL1095910 — — 1 7.38
CHEMBL46961 — — 2 7.36
CHEMBL420367 — — 1 7.34
CHEMBL58952 — — 1 7.33
CHEMBL352425 — — 1 7.32
CHEMBL58506 — — 1 7.25
CHEMBL65881 — — 1 7.11
CHEMBL167851 — — 1 7.06
CHEMBL423825 — — 1 7.02
CHEMBL420740 — — 1 6.84
CHEMBL307994 — — 1 6.80
CHEMBL69674 — — 1 6.80
CHEMBL168006 — — 1 6.74
CHEMBL58453 — — 1 6.73
CHEMBL165976 — — 1 6.64
CHEMBL298626 — — 1 6.36
CHEMBL164075 — — 1 6.32
CHEMBL291319 — — 1 6.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL354989 — IC50 = 3.02 nM 8.52
CHEMBL58711 TIVIRAPINE IC50 = 4.266 nM 8.37
CHEMBL351433 — IC50 = 5.012 nM 8.30
CHEMBL58119 — IC50 = 5.754 nM 8.24
CHEMBL66155 — IC50 = 12.02 nM 7.92
CHEMBL59279 — IC50 = 13.49 nM 7.87
CHEMBL304294 — IC50 = 22.91 nM 7.64
CHEMBL59131 — IC50 = 25.12 nM 7.60
CHEMBL293814 — IC50 = 25.12 nM 7.60
CHEMBL58811 — IC50 = 29.51 nM 7.53
CHEMBL293498 — IC50 = 33.88 nM 7.47
CHEMBL433931 — IC50 = 33.88 nM 7.47
CHEMBL1095910 — IC50 = 41.69 nM 7.38
CHEMBL46961 — IC50 = 43.65 nM 7.36
CHEMBL420367 — IC50 = 45.71 nM 7.34
CHEMBL58952 — IC50 = 46.77 nM 7.33
CHEMBL352425 — IC50 = 47.86 nM 7.32
CHEMBL58506 — IC50 = 56.23 nM 7.25
CHEMBL65881 — IC50 = 77.62 nM 7.11
CHEMBL167851 — IC50 = 87.1 nM 7.06
CHEMBL423825 — IC50 = 95.5 nM 7.02
CHEMBL46961 — IC50 = 97.72 nM 7.01
CHEMBL420740 — IC50 = 144.54 nM 6.84
CHEMBL69674 — IC50 = 158.49 nM 6.80
CHEMBL307994 — IC50 = 158.49 nM 6.80
CHEMBL168006 — IC50 = 181.97 nM 6.74
CHEMBL58453 — IC50 = 186.21 nM 6.73
CHEMBL165976 — IC50 = 229.09 nM 6.64
CHEMBL298626 — IC50 = 436.52 nM 6.36
CHEMBL164075 — IC50 = 478.63 nM 6.32
CHEMBL291319 — IC50 = 489.78 nM 6.31
CHEMBL354277 — IC50 = 676.08 nM 6.17
CHEMBL58493 — IC50 = 1000.0 nM 6.00
CHEMBL432516 — IC50 = 1071.52 nM 5.97
CHEMBL293271 — IC50 = 1148.15 nM 5.94
CHEMBL303241 — IC50 = 1148.15 nM 5.94
CHEMBL67451 — IC50 = 1659.59 nM 5.78
CHEMBL164579 — IC50 = 2187.76 nM 5.66
CHEMBL1094596 — IC50 = 2238.72 nM 5.65
CHEMBL65800 — IC50 = 2454.71 nM 5.61
CHEMBL60982 — IC50 = 2454.71 nM 5.61
CHEMBL59160 — IC50 = 5888.44 nM 5.23
CHEMBL167287 — IC50 = 6309.57 nM 5.20
CHEMBL167459 — IC50 = 6606.93 nM 5.18
CHEMBL349465 — IC50 = 6606.93 nM 5.18
CHEMBL166769 — IC50 = 6606.93 nM 5.18
CHEMBL69517 — IC50 = 12022.64 nM 4.92
CHEMBL292197 — IC50 = 12589.25 nM 4.90
CHEMBL69775 — IC50 = 12589.25 nM 4.90
CHEMBL1096897 — IC50 = 13489.63 nM 4.87