Assay Detail
Binding
CHEMBL1109953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT2
29
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aminofurazans as potent inhibitors of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.42 | 8.00 |
| Ki | 8 | 7.84 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1099297 | — | — | 2 | 9.00 |
| CHEMBL1098938 | — | — | 2 | 8.70 |
| CHEMBL494089 | GSK-690693 | 1.0 | 2 | 8.40 |
| CHEMBL1099276 | — | — | 2 | 8.30 |
| CHEMBL1098316 | — | — | 1 | 7.80 |
| CHEMBL1099296 | — | — | 2 | 7.77 |
| CHEMBL1098939 | — | — | 1 | 7.70 |
| CHEMBL1096626 | GSK-938890A | — | 1 | 7.70 |
| CHEMBL1096634 | GSK-943949A | — | 1 | 7.70 |
| CHEMBL1095624 | — | — | 1 | 7.60 |
| CHEMBL1099290 | — | — | 1 | 7.60 |
| CHEMBL1096291 | — | — | 2 | 7.41 |
| CHEMBL1097974 | — | — | 1 | 7.40 |
| CHEMBL1098944 | — | — | 1 | 7.30 |
| CHEMBL1099298 | — | — | 2 | 7.30 |
| CHEMBL1099281 | — | — | 1 | 7.20 |
| CHEMBL1098241 | — | — | 1 | 7.20 |
| CHEMBL1098943 | — | — | 1 | 7.10 |
| CHEMBL1096290 | GSK-1000163A | — | 1 | 6.70 |
| CHEMBL1096292 | — | — | 2 | 6.70 |
| CHEMBL1096636 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1099297 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1098938 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL494089 | GSK-690693 | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1099276 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1098938 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1098316 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1099297 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1099296 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1098939 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1096626 | GSK-938890A | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1096634 | GSK-943949A | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1099290 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1095624 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1099276 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1099296 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1096291 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1096291 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1097974 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1099298 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1098944 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1099281 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1098241 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1098943 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1099298 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL1096292 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1096290 | GSK-1000163A | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1096636 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL1096292 | — | Ki | = | 646.0 | nM | 6.19 |