Compound Detail
CHEMBL1098316
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1098316 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AXILYJJKIDQSFE-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
355.4
MW (Da)
0.93
ALogP
9
HBA
3
HBD
127.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| RAC-beta serine/threonine-protein kinase CHEMBL2431 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
| LNCaP CHEMBL612518 | IC50 | 6.7 | 6.7 | 201.0 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 6.52 | 6.52 | 303.0 | 1 |
| BT-474 CHEMBL614529 | IC50 | 6.36 | 6.36 | 439.0 | 1 |
| HFF CHEMBL614071 | IC50 | 5.23 | 5.23 | 5900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 3.0 | nM | 8.52 | Inhibition of AKT | 19179070 |
| RAC-beta serine/threonine-protein kinase | IC50 | = | 16.0 | nM | 7.8 | Inhibition of AKT2 | 19179070 |
| LNCaP | IC50 | = | 201.0 | nM | 6.7 | Antiproliferative activity against human LNCAP cells | 19179070 |
| Glycogen synthase kinase-3 beta | IC50 | = | 303.0 | nM | 6.52 | Inhibition of GSK3-beta phosphorylation in human BT474 cells | 19179070 |
| BT-474 | IC50 | = | 439.0 | nM | 6.36 | Antiproliferative activity against human BT474 cells | 19179070 |
| HFF | IC50 | = | 5900.0 | nM | 5.23 | Antiproliferative activity against human HFF cells | 19179070 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19179070 | 10.1016/j.bmcl.2009.01.002 | RAC-alpha serine/threonine-protein kinase | 1 |
| 19179070 | 10.1016/j.bmcl.2009.01.002 | RAC-beta serine/threonine-protein kinase | 1 |
| 19179070 | 10.1016/j.bmcl.2009.01.002 | RAC-gamma serine/threonine-protein kinase | 1 |
| 19179070 | 10.1016/j.bmcl.2009.01.002 | Glycogen synthase kinase-3 beta | 1 |
| 19179070 | 10.1016/j.bmcl.2009.01.002 | BT-474 | 1 |
| 19179070 | 10.1016/j.bmcl.2009.01.002 | LNCaP | 1 |
| 19179070 | 10.1016/j.bmcl.2009.01.002 | HFF | 1 |
Data from ChEMBL 36 via Core Engine