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Assay Detail

CHEMBL1109957

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human LNCAP cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LNCaP
Confidence 1 — Organism
Curated By Autocuration

Target

LNCaP (CHEMBL612518)
Type CELL-LINE
Organism Homo sapiens

Publication

Aminofurazans as potent inhibitors of AKT kinase.
Rouse MB, Seefeld MA, Leber JD, McNulty KC, Sun L, Miller WH, Zhang S, Minthorn EA, Concha NO, Choudhry AE, Schaber MD, Heerding DA.
Bioorg Med Chem Lett (2009) 19 : 1508 -1511
PubMed 19179070 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.66 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1099297 1 8.30
CHEMBL1098938 1 7.70
CHEMBL494089 GSK-690693 1.0 1 7.68
CHEMBL1099276 1 7.57
CHEMBL1099296 1 7.17
CHEMBL1099298 1 7.07
CHEMBL1098939 1 7.00
CHEMBL1099290 1 6.94
CHEMBL1096634 GSK-943949A 1 6.91
CHEMBL1096626 GSK-938890A 1 6.75
CHEMBL1098316 1 6.70
CHEMBL1098944 1 6.66
CHEMBL1098241 1 6.53
CHEMBL1096290 GSK-1000163A 1 6.50
CHEMBL1096291 1 6.30
CHEMBL1099281 1 6.25
CHEMBL1098943 1 6.05
CHEMBL1095624 1 5.70
CHEMBL1096292 1 5.50
CHEMBL1097974 1 5.33
CHEMBL1096636 1 5.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1099297 IC50 = 5.0 nM 8.30
CHEMBL1098938 IC50 = 20.0 nM 7.70
CHEMBL494089 GSK-690693 IC50 = 21.0 nM 7.68
CHEMBL1099276 IC50 = 27.0 nM 7.57
CHEMBL1099296 IC50 = 68.0 nM 7.17
CHEMBL1099298 IC50 = 85.0 nM 7.07
CHEMBL1098939 IC50 = 101.0 nM 7.00
CHEMBL1099290 IC50 = 114.0 nM 6.94
CHEMBL1096634 GSK-943949A IC50 = 124.0 nM 6.91
CHEMBL1096626 GSK-938890A IC50 = 176.0 nM 6.75
CHEMBL1098316 IC50 = 201.0 nM 6.70
CHEMBL1098944 IC50 = 220.0 nM 6.66
CHEMBL1098241 IC50 = 296.0 nM 6.53
CHEMBL1096290 GSK-1000163A IC50 = 313.0 nM 6.50
CHEMBL1096291 IC50 = 497.0 nM 6.30
CHEMBL1099281 IC50 = 560.0 nM 6.25
CHEMBL1098943 IC50 = 896.0 nM 6.05
CHEMBL1095624 IC50 = 2020.0 nM 5.70
CHEMBL1096292 IC50 = 3180.0 nM 5.50
CHEMBL1097974 IC50 = 4720.0 nM 5.33
CHEMBL1096636 IC50 = 6160.0 nM 5.21