Assay Detail
Binding
CHEMBL1109952
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Inhibition of AKT
29
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aminofurazans as potent inhibitors of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.37 | 9.22 |
| Ki | 8 | 8.78 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1098938 | — | — | 2 | 9.70 |
| CHEMBL1099297 | — | — | 2 | 9.70 |
| CHEMBL1099276 | — | — | 2 | 9.40 |
| CHEMBL494089 | GSK-690693 | 1.0 | 2 | 9.00 |
| CHEMBL1099298 | — | — | 2 | 8.72 |
| CHEMBL1099290 | — | — | 1 | 8.70 |
| CHEMBL1098939 | — | — | 1 | 8.52 |
| CHEMBL1096634 | GSK-943949A | — | 1 | 8.52 |
| CHEMBL1099296 | — | — | 2 | 8.52 |
| CHEMBL1098316 | — | — | 1 | 8.52 |
| CHEMBL1097974 | — | — | 1 | 8.52 |
| CHEMBL1095624 | — | — | 1 | 8.40 |
| CHEMBL1096291 | — | — | 2 | 8.30 |
| CHEMBL1096626 | GSK-938890A | — | 1 | 8.30 |
| CHEMBL1096290 | GSK-1000163A | — | 1 | 8.22 |
| CHEMBL1098241 | — | — | 1 | 8.22 |
| CHEMBL1098944 | — | — | 1 | 8.10 |
| CHEMBL1098943 | — | — | 1 | 7.92 |
| CHEMBL1099281 | — | — | 1 | 7.89 |
| CHEMBL1096292 | — | — | 2 | 7.80 |
| CHEMBL1096636 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1098938 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1099297 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1099276 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL1098938 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL494089 | GSK-690693 | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1099276 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1099298 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1099290 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1099297 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1097974 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1099296 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1098316 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1099296 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1098939 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1096634 | GSK-943949A | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1099298 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1095624 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1096626 | GSK-938890A | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1096291 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1096290 | GSK-1000163A | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1098241 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1096291 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1098944 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1098943 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1099281 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1096292 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1096636 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1096292 | — | Ki | = | 115.0 | nM | 6.94 |