Assay Detail
Functional
CHEMBL1109958
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Antiproliferative activity against human HFF cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aminofurazans as potent inhibitors of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.87 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1099276 | — | — | 1 | 6.29 |
| CHEMBL1096291 | — | — | 1 | 5.30 |
| CHEMBL1096634 | GSK-943949A | — | 1 | 5.30 |
| CHEMBL1098316 | — | — | 1 | 5.23 |
| CHEMBL1098939 | — | — | 1 | 5.16 |
| CHEMBL1098938 | — | — | 1 | 5.10 |
| CHEMBL1099297 | — | — | 1 | 4.96 |
| CHEMBL1098944 | — | — | 1 | 4.77 |
| CHEMBL1098943 | — | — | 1 | 4.77 |
| CHEMBL1099296 | — | — | 1 | 4.70 |
| CHEMBL1096626 | GSK-938890A | — | 1 | 4.70 |
| CHEMBL1097974 | — | — | 1 | 4.64 |
| CHEMBL1098241 | — | — | 1 | 4.62 |
| CHEMBL1095624 | — | — | 1 | 4.62 |
| CHEMBL1099281 | — | — | 1 | 4.55 |
| CHEMBL1099298 | — | — | 1 | 4.54 |
| CHEMBL1096636 | — | — | 1 | 4.52 |
| CHEMBL1096292 | — | — | 1 | 4.52 |
| CHEMBL1099290 | — | — | 1 | 4.52 |
| CHEMBL1096290 | GSK-1000163A | — | 1 | 4.52 |
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1099276 | — | IC50 | = | 519.0 | nM | 6.29 |
| CHEMBL1096291 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1096634 | GSK-943949A | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1098316 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1098939 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1098938 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1099297 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1098944 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1098943 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1099296 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1096626 | GSK-938890A | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1097974 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1098241 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1095624 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1099281 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1099298 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1096636 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1096292 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1099290 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1096290 | GSK-1000163A | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL494089 | GSK-690693 | IC50 | > | 23000.0 | nM | - |