Assay Detail
Binding
CHEMBL1109955
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Inhibition of GSK3-beta phosphorylation in human BT474 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aminofurazans as potent inhibitors of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.07 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1099276 | — | — | 1 | 7.40 |
| CHEMBL1099297 | — | — | 1 | 7.39 |
| CHEMBL1098938 | — | — | 1 | 7.10 |
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 6.86 |
| CHEMBL1099296 | — | — | 1 | 6.72 |
| CHEMBL1098316 | — | — | 1 | 6.52 |
| CHEMBL1098939 | — | — | 1 | 6.51 |
| CHEMBL1099290 | — | — | 1 | 6.43 |
| CHEMBL1098944 | — | — | 1 | 6.40 |
| CHEMBL1098241 | — | — | 1 | 5.99 |
| CHEMBL1096626 | GSK-938890A | — | 1 | 5.98 |
| CHEMBL1096634 | GSK-943949A | — | 1 | 5.96 |
| CHEMBL1096291 | — | — | 1 | 5.94 |
| CHEMBL1099281 | — | — | 1 | 5.92 |
| CHEMBL1099298 | — | — | 1 | 5.80 |
| CHEMBL1098943 | — | — | 1 | 5.58 |
| CHEMBL1096290 | GSK-1000163A | — | 1 | 5.57 |
| CHEMBL1095624 | — | — | 1 | 5.40 |
| CHEMBL1097974 | — | — | 1 | 4.88 |
| CHEMBL1096292 | — | — | 1 | 4.52 |
| CHEMBL1096636 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1099276 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1099297 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1098938 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL1099296 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1098316 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL1098939 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1099290 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL1098944 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1098241 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL1096626 | GSK-938890A | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1096634 | GSK-943949A | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL1096291 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL1099281 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL1099298 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL1098943 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1096290 | GSK-1000163A | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1095624 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1097974 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL1096292 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1096636 | — | IC50 | = | 30000.0 | nM | 4.52 |