Assay Detail
Binding
CHEMBL1109954
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT3
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aminofurazans as potent inhibitors of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.76 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1099276 | — | — | 1 | 9.00 |
| CHEMBL1098938 | — | — | 1 | 8.52 |
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 8.05 |
| CHEMBL1096634 | GSK-943949A | — | 1 | 7.77 |
| CHEMBL1096290 | GSK-1000163A | — | 1 | 7.66 |
| CHEMBL1097974 | — | — | 1 | 7.52 |
| CHEMBL1096291 | — | — | 1 | 7.37 |
| CHEMBL1096626 | GSK-938890A | — | 1 | 7.31 |
| CHEMBL1099298 | — | — | 1 | 7.19 |
| CHEMBL1098241 | — | — | 1 | 7.16 |
| CHEMBL1095624 | — | — | 1 | - |
| CHEMBL1098316 | — | — | 1 | - |
| CHEMBL1099290 | — | — | 1 | - |
| CHEMBL1096292 | — | — | 1 | - |
| CHEMBL1096636 | — | — | 1 | - |
| CHEMBL1098944 | — | — | 1 | - |
| CHEMBL1098943 | — | — | 1 | - |
| CHEMBL1099281 | — | — | 1 | - |
| CHEMBL1098939 | — | — | 1 | - |
| CHEMBL1099296 | — | — | 1 | - |
| CHEMBL1099297 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1099276 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1098938 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1096634 | GSK-943949A | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1096290 | GSK-1000163A | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1097974 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1096291 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1096626 | GSK-938890A | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1099298 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1098241 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1095624 | — | IC50 | - | — | - | |
| CHEMBL1098316 | — | IC50 | - | — | - | |
| CHEMBL1099290 | — | IC50 | - | — | - | |
| CHEMBL1096292 | — | IC50 | - | — | - | |
| CHEMBL1096636 | — | IC50 | - | — | - | |
| CHEMBL1098944 | — | IC50 | - | — | - | |
| CHEMBL1098943 | — | IC50 | - | — | - | |
| CHEMBL1099281 | — | IC50 | - | — | - | |
| CHEMBL1098939 | — | IC50 | - | — | - | |
| CHEMBL1099296 | — | IC50 | - | — | - | |
| CHEMBL1099297 | — | IC50 | - | — | - |