Assay Detail
Functional
CHEMBL1109970
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Antiproliferative activity against human MCF7 cells expressing BCA2 and estrogen receptor after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.45 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121516 | BIS(PIPERIDINYLTHIOCARBONYL)DISULFIDE | — | 1 | 7.52 |
| CHEMBL964 | DISULFIRAM | 4.0 | 1 | 7.00 |
| CHEMBL1099261 | CYCLOHEXYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | — | 1 | 6.52 |
| CHEMBL571699 | — | — | 1 | 6.46 |
| CHEMBL583959 | BIS(PYRROLIDINYLTHIOCARBONYL)DISULFIDE | — | 1 | 6.42 |
| CHEMBL1097570 | ISOPROPYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | — | 1 | 6.41 |
| CHEMBL1098279 | BUTYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | — | 1 | 6.40 |
| CHEMBL1097571 | DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | — | 1 | 6.37 |
| CHEMBL1098280 | — | — | 1 | 6.35 |
| CHEMBL1094278 | — | — | 1 | 6.30 |
| CHEMBL1097576 | — | — | 1 | 6.30 |
| CHEMBL1096609 | — | — | 1 | 6.22 |
| CHEMBL1096608 | — | — | 1 | 6.19 |
| CHEMBL1096610 | — | — | 1 | 5.85 |
| CHEMBL582932 | DITHIODIMORPHOLINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121516 | BIS(PIPERIDINYLTHIOCARBONYL)DISULFIDE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL964 | DISULFIRAM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1099261 | CYCLOHEXYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL571699 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL583959 | BIS(PYRROLIDINYLTHIOCARBONYL)DISULFIDE | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1097570 | ISOPROPYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1098279 | BUTYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1097571 | DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1098280 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1094278 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1097576 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1096609 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1096608 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1096610 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL582932 | DITHIODIMORPHOLINE | IC50 | > | 10000.0 | nM | - |