Assay Detail
Functional
CHEMBL1109972
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Antiproliferative activity against human MDA-MB-231 cells expressing BCA2 and ERalpha after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.30 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL583959 | BIS(PYRROLIDINYLTHIOCARBONYL)DISULFIDE | — | 1 | 6.60 |
| CHEMBL1097570 | ISOPROPYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | — | 1 | 6.60 |
| CHEMBL1096610 | — | — | 1 | 6.60 |
| CHEMBL1099261 | CYCLOHEXYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | — | 1 | 6.55 |
| CHEMBL571699 | — | — | 1 | 6.54 |
| CHEMBL1098279 | BUTYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | — | 1 | 6.52 |
| CHEMBL964 | DISULFIRAM | 4.0 | 1 | 6.50 |
| CHEMBL1097571 | DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | — | 1 | 6.46 |
| CHEMBL1096608 | — | — | 1 | 6.41 |
| CHEMBL1097576 | — | — | 1 | 6.26 |
| CHEMBL121516 | BIS(PIPERIDINYLTHIOCARBONYL)DISULFIDE | — | 1 | 6.23 |
| CHEMBL1098280 | — | — | 1 | 5.68 |
| CHEMBL1096609 | — | — | 1 | 5.64 |
| CHEMBL1094278 | — | — | 1 | 5.56 |
| CHEMBL582932 | DITHIODIMORPHOLINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL583959 | BIS(PYRROLIDINYLTHIOCARBONYL)DISULFIDE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1097570 | ISOPROPYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1096610 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1099261 | CYCLOHEXYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL571699 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1098279 | BUTYL DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL964 | DISULFIRAM | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1097571 | DIETHYLCARBAMO(DITHIOPEROXO)THIOATE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1096608 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1097576 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL121516 | BIS(PIPERIDINYLTHIOCARBONYL)DISULFIDE | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1098280 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1096609 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1094278 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL582932 | DITHIODIMORPHOLINE | IC50 | > | 10000.0 | nM | - |