Assay Detail
Binding
CHEMBL1110033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Geranylgeranyl pyrophosphate synthase (CHEMBL4769) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.17 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319144 | MINODRONIC ACID | 4.0 | 1 | 6.17 |
| CHEMBL1099309 | (2-HYDROXY-3-IMIDAZO[1,2-A]PYRIDIN-3-YL-2-PHOSPHONOPROPIONIC ACID (ENANTIONMERS) | — | 3 | - |
| CHEMBL397829 | — | — | 3 | - |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319144 | MINODRONIC ACID | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1099309 | (2-HYDROXY-3-IMIDAZO[1,2-A]PYRIDIN-3-YL-2-PHOSPHONOPROPIONIC ACID (ENANTIONMERS) | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1099309 | (2-HYDROXY-3-IMIDAZO[1,2-A]PYRIDIN-3-YL-2-PHOSPHONOPROPIONIC ACID (ENANTIONMERS) | IC50 | > | 1000000.0 | nM | - |
| CHEMBL397829 | — | IC50 | - | — | - | |
| CHEMBL397829 | — | IC50 | - | — | - | |
| CHEMBL397829 | — | IC50 | - | — | - | |
| CHEMBL1099309 | (2-HYDROXY-3-IMIDAZO[1,2-A]PYRIDIN-3-YL-2-PHOSPHONOPROPIONIC ACID (ENANTIONMERS) | IC50 | - | — | - | |
| CHEMBL923 | RISEDRONIC ACID | IC50 | - | — | - |