Assay Detail
Functional
CHEMBL1110057
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human HOS cells expressing human CXCR4/CCR5/CD4/pHIV-LTR luciferase assessed as inhibition of viral infection to cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HOS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and SAR of novel isoquinoline CXCR4 antagonists with potent anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.56 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL568653 | — | — | 1 | 8.70 |
| CHEMBL1096504 | — | — | 1 | 8.30 |
| CHEMBL518924 | MAVORIXAFOR | 4.0 | 1 | 8.00 |
| CHEMBL1098464 | — | — | 1 | 7.96 |
| CHEMBL1094870 | — | — | 1 | 7.92 |
| CHEMBL1094864 | — | — | 1 | 7.92 |
| CHEMBL1098156 | — | — | 1 | 7.92 |
| CHEMBL1096503 | — | — | 1 | 7.92 |
| CHEMBL1096154 | — | — | 1 | 7.80 |
| CHEMBL1096505 | — | — | 1 | 7.77 |
| CHEMBL568447 | — | — | 1 | 7.77 |
| CHEMBL1097110 | — | — | 1 | 7.70 |
| CHEMBL1094871 | — | — | 1 | 7.68 |
| CHEMBL1088913 | — | — | 1 | 7.64 |
| CHEMBL1097108 | — | — | 1 | 7.57 |
| CHEMBL1097821 | — | — | 1 | 7.47 |
| CHEMBL1098199 | — | — | 1 | 7.42 |
| CHEMBL1094245 | — | — | 1 | 7.39 |
| CHEMBL1097461 | — | — | 1 | 7.38 |
| CHEMBL1095179 | — | — | 1 | 7.36 |
| CHEMBL1097109 | — | — | 1 | 7.32 |
| CHEMBL1099015 | — | — | 1 | 7.16 |
| CHEMBL1096141 | — | — | 1 | 7.14 |
| CHEMBL1097459 | — | — | 1 | 6.92 |
| CHEMBL1097505 | — | — | 1 | 6.80 |
| CHEMBL1097504 | — | — | 1 | 6.70 |
| CHEMBL1099358 | — | — | 1 | 6.47 |
| CHEMBL1097460 | — | — | 1 | - |
| CHEMBL1097820 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL568653 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1096504 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL518924 | MAVORIXAFOR | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1098464 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1094870 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1094864 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1098156 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1096503 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1096154 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1096505 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL568447 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1097110 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1094871 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1088913 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1097108 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1097821 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1098199 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1094245 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1097461 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1095179 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1097109 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1099015 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1096141 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1097459 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1097505 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1097504 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1099358 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1097460 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1097820 | — | IC50 | > | 20000.0 | nM | - |