Assay Detail
Binding
CHEMBL1110122
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Inhibition of mouse brain POP
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.52 | 9.46 |
| IC50 | 1 | 8.33 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79993 | Z-PRO-PROLINAL | — | 1 | 9.46 |
| CHEMBL1086705 | — | — | 1 | 8.62 |
| CHEMBL155614 | — | — | 1 | 8.52 |
| CHEMBL289651 | — | — | 1 | 8.33 |
| CHEMBL1097128 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79993 | Z-PRO-PROLINAL | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL1086705 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL155614 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL289651 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL1097128 | — | Ki | = | 33.0 | nM | 7.48 |