Compound Detail
CHEMBL155614
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Basic Information
| ChEMBL ID | CHEMBL155614 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGIVEXIVTQQIPV-BZSNNMDCSA-N |
1
Targets
2
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
343.4
MW (Da)
2.73
ALogP
4
HBA
0
HBD
63.7
PSA (Ų)
0.61
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl endopeptidase CHEMBL4935 | Ki | 8.52 | 8.52 | 3.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 3.0 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl endopeptidase | Ki | = | 3.0 | nM | 8.52 | Compound was evaluated for binding inhibition against Prolyl Endopeptidase (PEP)... | - |
| Prolyl endopeptidase | Ki | = | 3.0 | nM | 8.52 | Inhibition of mouse brain POP | 20058865 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)81156-2 | Prolyl endopeptidase | 4 |
| - | 10.1016/S0960-894X(01)81156-2 | Mus musculus | 1 |
| 20058865 | 10.1021/jm901104g | Prolyl endopeptidase | 1 |
Data from ChEMBL 36 via Core Engine