Assay Detail
Functional
CHEMBL1111159
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Agonist activity at human recombinant S1P5 receptor expressed in CHO cells by GTPgammaS binding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.08 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095833 | — | — | 1 | 7.23 |
| CHEMBL225155 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095833 | — | EC50 | = | 59.1 | nM | 7.23 |
| CHEMBL225155 | — | EC50 | = | 121.0 | nM | 6.92 |