Assay Detail
Binding
CHEMBL1111164
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Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.85 | 6.85 |
| EC50 | 1 | 9.70 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225155 | — | — | 1 | 9.70 |
| CHEMBL1095833 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225155 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1095833 | — | IC50 | = | 142.0 | nM | 6.85 |