Assay Detail
Binding
CHEMBL1111210
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at androgen receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.60 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491 | HYDROXYFLUTAMIDE | 2.0 | 1 | 7.60 |
| CHEMBL1087512 | LECANINDOLE B | — | 1 | - |
| CHEMBL1076438 | LECANINDOLE D | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491 | HYDROXYFLUTAMIDE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1087512 | LECANINDOLE B | IC50 | > | 10000.0 | nM | - |
| CHEMBL1076438 | LECANINDOLE D | IC50 | > | 10000.0 | nM | - |