Assay Detail
Binding
CHEMBL1111474
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Inhibition of EGFR
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selectively nonselective kinase inhibition: striking the right balance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.13 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 9.00 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 8.70 |
| CHEMBL598797 | CUDC-101 | 1.0 | 1 | 8.62 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 8.00 |
| CHEMBL2374457 | — | — | 1 | 7.24 |
| CHEMBL2374458 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL598797 | CUDC-101 | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL554 | LAPATINIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2374457 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2374458 | — | IC50 | = | 58.0 | nM | 7.24 |