Assay Detail
Binding
CHEMBL1111477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Akt1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selectively nonselective kinase inhibition: striking the right balance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.68 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521642 | — | — | 1 | 8.70 |
| CHEMBL447328 | — | — | 1 | 8.40 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 8.10 |
| CHEMBL258844 | — | — | 1 | 7.24 |
| CHEMBL493911 | — | — | 1 | 7.10 |
| CHEMBL182101 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521642 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL447328 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL258844 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL493911 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL182101 | — | IC50 | = | 273.0 | nM | 6.56 |