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Assay Detail

CHEMBL1111547

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Eukaryotic elongation factor 2 kinase (CHEMBL5026)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues.
Lockman JW, Reeder MD, Suzuki K, Ostanin K, Hoff R, Bhoite L, Austin H, Baichwal V, Adam Willardsen J.
Bioorg Med Chem Lett (2010) 20 : 2283 -2286
PubMed 20189382 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 6.08 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1094018 1 6.96
CHEMBL1092820 1 6.77
CHEMBL1091317 1 6.66
CHEMBL1094026 1 6.55
CHEMBL1089019 1 6.52
CHEMBL1091829 1 6.50
CHEMBL1091074 1 6.48
CHEMBL1091450 1 6.46
CHEMBL1091830 1 6.34
CHEMBL1094038 1 6.19
CHEMBL1091075 1 6.18
CHEMBL1091459 1 6.10
CHEMBL1090045 1 6.07
CHEMBL1089016 1 6.07
CHEMBL1089330 1 6.03
CHEMBL1093057 1 6.00
CHEMBL1092378 1 6.00
CHEMBL1091460 1 5.96
CHEMBL1093963 1 5.96
CHEMBL1089331 1 5.96
CHEMBL1093355 1 5.96
CHEMBL1091709 1 5.96
CHEMBL1092033 1 5.92
CHEMBL1090401 1 5.89
CHEMBL1090389 1 5.85
CHEMBL1089017 1 5.70
CHEMBL1089006 1 5.60
CHEMBL1091449 1 5.43
CHEMBL1089956 1 5.33
CHEMBL1093056 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1094018 IC50 = 110.0 nM 6.96
CHEMBL1092820 IC50 = 170.0 nM 6.77
CHEMBL1091317 IC50 = 220.0 nM 6.66
CHEMBL1094026 IC50 = 280.0 nM 6.55
CHEMBL1089019 IC50 = 300.0 nM 6.52
CHEMBL1091829 IC50 = 320.0 nM 6.50
CHEMBL1091074 IC50 = 330.0 nM 6.48
CHEMBL1091450 IC50 = 350.0 nM 6.46
CHEMBL1091830 IC50 = 460.0 nM 6.34
CHEMBL1094038 IC50 = 640.0 nM 6.19
CHEMBL1091075 IC50 = 660.0 nM 6.18
CHEMBL1091459 IC50 = 800.0 nM 6.10
CHEMBL1090045 IC50 = 860.0 nM 6.07
CHEMBL1089016 IC50 = 860.0 nM 6.07
CHEMBL1089330 IC50 = 940.0 nM 6.03
CHEMBL1093057 IC50 = 990.0 nM 6.00
CHEMBL1092378 IC50 = 990.0 nM 6.00
CHEMBL1091709 IC50 = 1100.0 nM 5.96
CHEMBL1093355 IC50 = 1100.0 nM 5.96
CHEMBL1093963 IC50 = 1100.0 nM 5.96
CHEMBL1091460 IC50 = 1100.0 nM 5.96
CHEMBL1089331 IC50 = 1100.0 nM 5.96
CHEMBL1092033 IC50 = 1200.0 nM 5.92
CHEMBL1090401 IC50 = 1300.0 nM 5.89
CHEMBL1090389 IC50 = 1400.0 nM 5.85
CHEMBL1089017 IC50 = 2000.0 nM 5.70
CHEMBL1089006 IC50 = 2500.0 nM 5.60
CHEMBL1091449 IC50 = 3700.0 nM 5.43
CHEMBL1089956 IC50 = 4700.0 nM 5.33
CHEMBL1093056 IC50 = 10000.0 nM 5.00
CHEMBL1092819 IC50 > 20000.0 nM -
CHEMBL1089712 IC50 > 20000.0 nM -
CHEMBL1093095 IC50 > 20000.0 nM -
CHEMBL1090013 IC50 > 10000.0 nM -
CHEMBL1092769 IC50 > 10000.0 nM -
CHEMBL1089298 IC50 > 10000.0 nM -
CHEMBL1090391 IC50 > 20000.0 nM -
CHEMBL1090390 IC50 > 20000.0 nM -
CHEMBL1091783 IC50 > 20000.0 nM -
CHEMBL1090044 IC50 > 20000.0 nM -