Compound Detail
CHEMBL1089019
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Basic Information
| ChEMBL ID | CHEMBL1089019 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VHLDQURHHUWKSX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
409.4
MW (Da)
4.92
ALogP
5
HBA
2
HBD
95.1
PSA (Ų)
0.63
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eukaryotic elongation factor 2 kinase CHEMBL5026 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eukaryotic elongation factor 2 kinase | IC50 | = | 300.0 | nM | 6.52 | Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric met... | 20189382 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20189382 | 10.1016/j.bmcl.2010.02.005 | Eukaryotic elongation factor 2 kinase | 1 |
Data from ChEMBL 36 via Core Engine