Assay Detail
Binding
CHEMBL1111767
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Inhibition of human recombinant cytosolic thymidine kinase 1 assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation counting
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.18 | 4.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090132 | — | — | 1 | 4.27 |
| CHEMBL1089867 | — | — | 1 | 4.15 |
| CHEMBL1090868 | — | — | 1 | 4.12 |
| CHEMBL1092729 | — | — | 1 | - |
| CHEMBL1089805 | — | — | 1 | - |
| CHEMBL1090133 | — | — | 1 | - |
| CHEMBL1090134 | — | — | 1 | - |
| CHEMBL1091719 | — | — | 1 | - |
| CHEMBL1090869 | — | — | 1 | - |
| CHEMBL1091210 | — | — | 1 | - |
| CHEMBL1091931 | — | — | 1 | - |
| CHEMBL1091988 | — | — | 1 | - |
| CHEMBL1092055 | — | — | 1 | - |
| CHEMBL1091873 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090132 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL1089867 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL1090868 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL1092729 | — | IC50 | >= | 500000.0 | nM | - |
| CHEMBL1089805 | — | IC50 | = | 366000.0 | nM | - |
| CHEMBL1090133 | — | IC50 | = | 318000.0 | nM | - |
| CHEMBL1090134 | — | IC50 | = | 177000.0 | nM | - |
| CHEMBL1091719 | — | IC50 | = | 316000.0 | nM | - |
| CHEMBL1090869 | — | IC50 | >= | 500000.0 | nM | - |
| CHEMBL1091210 | — | IC50 | = | 109000.0 | nM | - |
| CHEMBL1091931 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1091988 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1092055 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1091873 | — | IC50 | = | 316000.0 | nM | - |