Assay Detail
Functional
CHEMBL1111804
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Inhibition of LPS-induced TNFalpha production in human whole blood by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.96 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088752 | LOSMAPIMOD | 3.0 | 1 | 7.60 |
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 1 | 6.75 |
| CHEMBL514201 | TALMAPIMOD | 2.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088752 | LOSMAPIMOD | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL119385 | NEFLAMAPIMOD | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL514201 | TALMAPIMOD | IC50 | = | 300.0 | nM | 6.52 |