Assay Detail
Binding
CHEMBL1111805
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Binding affinity to p38alpha
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.88 | 9.32 |
| Ki | 2 | 8.17 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514201 | TALMAPIMOD | 2.0 | 1 | 9.32 |
| CHEMBL1090089 | PAMAPIMOD | 2.0 | 1 | 8.89 |
| CHEMBL1090090 | VX-702 | 2.0 | 1 | 8.43 |
| CHEMBL1088751 | PH-797804 | 2.0 | 1 | 8.24 |
| CHEMBL1088752 | LOSMAPIMOD | 3.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514201 | TALMAPIMOD | Kd | = | 0.48 | nM | 9.32 |
| CHEMBL1090089 | PAMAPIMOD | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL1090090 | VX-702 | Kd | = | 3.7 | nM | 8.43 |
| CHEMBL1088751 | PH-797804 | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL1088752 | LOSMAPIMOD | Ki | = | 7.943 | nM | 8.10 |