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Assay Detail

CHEMBL1112282

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cell cycle arrest in human HCT116 cells assessed as accumulation of 4N DNA by FACS analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

2-Aminobenzimidazoles as potent Aurora kinase inhibitors.
Zhong M, Bui M, Shen W, Baskaran S, Allen DA, Elling RA, Flanagan WM, Fung AD, Hanan EJ, Harris SO, Heumann SA, Hoch U, Ivy SN, Jacobs JW, Lam S, Lee H, McDowell RS, Oslob JD, Purkey HE, Romanowski MJ, Silverman JA, Tangonan BT, Taverna P, Yang W, Yoburn JC, Yu CH, Zimmerman KM, O'Brien T, Lew W.
Bioorg Med Chem Lett (2009) 19 : 5158 -5161
PubMed 19646866 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 24 7.60 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1078060 1 7.80
CHEMBL1077729 1 7.80
CHEMBL472202 1 7.80
CHEMBL1079713 1 7.80
CHEMBL1081880 1 7.20
CHEMBL1078061 1 7.20
CHEMBL472193 1 -
CHEMBL518051 SNS-314 MESYLATE 1 -
CHEMBL1078827 1 -
CHEMBL1078828 1 -
CHEMBL1078926 1 -
CHEMBL1078927 1 -
CHEMBL1078327 1 -
CHEMBL1078906 1 -
CHEMBL1077955 1 -
CHEMBL1079051 1 -
CHEMBL1079052 1 -
CHEMBL1079271 1 -
CHEMBL1081881 1 -
CHEMBL1079538 1 -
CHEMBL1080080 1 -
CHEMBL1080980 1 -
CHEMBL1080981 1 -
CHEMBL1079150 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1078060 EC50 = 16.0 nM 7.80
CHEMBL1077729 EC50 = 16.0 nM 7.80
CHEMBL472202 EC50 = 16.0 nM 7.80
CHEMBL1079713 EC50 = 16.0 nM 7.80
CHEMBL1081880 EC50 = 63.0 nM 7.20
CHEMBL1078061 EC50 = 63.0 nM 7.20
CHEMBL472193 EC50 < 16.0 nM -
CHEMBL518051 SNS-314 MESYLATE EC50 < 16.0 nM -
CHEMBL1078827 EC50 - -
CHEMBL1078828 EC50 - -
CHEMBL1078926 EC50 - -
CHEMBL1078927 EC50 - -
CHEMBL1078327 EC50 - -
CHEMBL1078906 EC50 - -
CHEMBL1077955 EC50 - -
CHEMBL1079051 EC50 - -
CHEMBL1079052 EC50 - -
CHEMBL1079271 EC50 - -
CHEMBL1081881 EC50 - -
CHEMBL1079538 EC50 < 16.0 nM -
CHEMBL1080080 EC50 - -
CHEMBL1080980 EC50 - -
CHEMBL1080981 EC50 - -
CHEMBL1079150 EC50 - -