Assay Detail
Functional
CHEMBL1112367
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Cytotoxicity against human HCT116 cells after 72 hrs by MTS/PMS assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.66 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077383 | SALINOSPORAMIDE X7 | — | 1 | 8.23 |
| CHEMBL371405 | MARIZOMIB | 3.0 | 1 | 7.80 |
| CHEMBL1081673 | — | — | 1 | 7.27 |
| CHEMBL192046 | — | — | 1 | 6.75 |
| CHEMBL1081854 | SALINOSPORAMIDE X3 | — | 1 | 6.73 |
| CHEMBL561240 | ANTIPROTEALIDE | — | 1 | 6.11 |
| CHEMBL1080762 | SALINOSPORAMIDE X6 | — | 1 | 5.96 |
| CHEMBL1077389 | SALINOSPORAMIDE X5 | — | 1 | 5.96 |
| CHEMBL1080230 | SALINOSPORAMIDE X4 | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077383 | SALINOSPORAMIDE X7 | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL371405 | MARIZOMIB | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1081673 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL192046 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL1081854 | SALINOSPORAMIDE X3 | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL561240 | ANTIPROTEALIDE | IC50 | = | 777.0 | nM | 6.11 |
| CHEMBL1080762 | SALINOSPORAMIDE X6 | IC50 | = | 1108.0 | nM | 5.96 |
| CHEMBL1077389 | SALINOSPORAMIDE X5 | IC50 | = | 1094.0 | nM | 5.96 |
| CHEMBL1080230 | SALINOSPORAMIDE X4 | IC50 | = | 6877.0 | nM | 5.16 |