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Assay Detail

CHEMBL1112845

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Functional
Antiplasmodial activity against Plasmodium falciparum K1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
Branowska D, Farahat AA, Kumar A, Wenzler T, Brun R, Liu Y, Wilson WD, Boykin DW.
Bioorg Med Chem (2010) 18 : 3551 -3558
PubMed 20403703 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 8.14 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3216253 1 8.96
CHEMBL3215509 1 8.70
CHEMBL3216696 1 8.62
CHEMBL3215600 1 8.60
CHEMBL145251 1 8.19
CHEMBL3216465 1 7.90
CHEMBL3216050 1 7.89
CHEMBL24057 FURAMIDINE -1.0 1 7.86
CHEMBL165542 1 7.86
CHEMBL3216698 1 7.61
CHEMBL55 PENTAMIDINE 4.0 1 7.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3216253 IC50 = 1.1 nM 8.96
CHEMBL3215509 IC50 = 2.0 nM 8.70
CHEMBL3216696 IC50 = 2.4 nM 8.62
CHEMBL3215600 IC50 = 2.5 nM 8.60
CHEMBL145251 IC50 = 6.5 nM 8.19
CHEMBL3216465 IC50 = 12.5 nM 7.90
CHEMBL3216050 IC50 = 13.0 nM 7.89
CHEMBL24057 FURAMIDINE IC50 = 13.8 nM 7.86
CHEMBL165542 IC50 = 13.8 nM 7.86
CHEMBL3216698 IC50 = 24.6 nM 7.61
CHEMBL55 PENTAMIDINE IC50 = 46.4 nM 7.33