Compound Detail
CHEMBL24057
FURAMIDINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL24057 |
| Name | FURAMIDINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZJHZBDRZEZEDGB-UHFFFAOYSA-N |
19
Targets
101
Activities
2
Assay Types
3
PK Parameters
20
Publications
4
Known Names
Molecular Properties
304.4
MW (Da)
3.18
ALogP
3
HBA
4
HBD
112.9
PSA (Ų)
0.44
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Achiral |
Activity Summary
IC50 97 meas. best 9.3
Kd 4 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 9.3 | 7.6117 | 0.5 | 23 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 8.57 | 6.2617 | 2.7 | 6 |
| Leishmania donovani CHEMBL367 | IC50 | 8.55 | 6.5633 | 2.8 | 3 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 8.52 | 8.0881 | 3.0 | 21 |
| Mus musculus CHEMBL375 | IC50 | 8.35 | 8.35 | 4.5 | 1 |
| L6 CHEMBL614793 | IC50 | 8.19 | 5.3729 | 6.4 | 14 |
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 8.15 | 6.425 | 7.0 | 2 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] CHEMBL3959 | IC50 | 7.46 | 7.46 | 35.0 | 1 |
| Unchecked CHEMBL612545 | Kd | 7.0 | 6.7175 | 100.0 | 4 |
| Giardia intestinalis CHEMBL612652 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| Protein arginine N-methyltransferase 1 CHEMBL5524 | IC50 | 6.51 | 5.3125 | 310.0 | 4 |
| Tyrosyl-DNA phosphodiesterase 1 CHEMBL1075138 | IC50 | 6.0 | 5.4617 | 1000.0 | 6 |
| Leishmania sp. CHEMBL612241 | IC50 | 5.55 | 5.55 | 2800.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 5.37 | 5.25 | 4230.0 | 2 |
| Molecular identity unknown CHEMBL612546 | IC50 | 5.19 | 5.19 | 6400.0 | 1 |
| B16 CHEMBL381 | IC50 | 5.04 | 5.04 | 9200.0 | 1 |
| A2780 CHEMBL614004 | IC50 | 4.81 | 4.575 | 15500.0 | 2 |
| SK-OV-3 CHEMBL614925 | IC50 | 4.37 | 4.37 | 42500.0 | 1 |
| CH1 CHEMBL614455 | IC50 | 4.33 | 4.33 | 46500.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 8.0 | nM | Mus musculus |
| F | 0.2 | % | Mus musculus |
| T1/2 | 107.0 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(96)00557-4 | Rattus norvegicus | 14 |
| 336890 | 10.1021/jm00219a023 | Trypanosoma brucei rhodesiense | 9 |
| 18086841 | 10.1128/aac.00642-07 | Trypanosoma brucei brucei | 9 |
| 19620327 | 10.1128/aac.00225-09 | Trypanosoma brucei rhodesiense | 7 |
| 19786604 | 10.1128/aac.00422-09 | Trypanosoma evansi | 6 |
| 24564570 | 10.1021/jm401884z | Protein arginine N-methyltransferase 1 | 6 |
| 19620327 | 10.1128/aac.00225-09 | Trypanosoma brucei brucei | 6 |
| 16913722 | 10.1021/jm060470p | Mus musculus | 4 |
| 9748362 | 10.1021/jm980230c | ADMET | 4 |
| 9748362 | 10.1021/jm980230c | Rattus norvegicus | 4 |
| 19620327 | 10.1128/aac.00225-09 | Trypanosoma brucei gambiense | 4 |
| 26117647 | 10.1016/j.bmc.2015.06.012 | Glutamate NMDA receptor | 4 |
| 20457822 | 10.1128/aac.01617-09 | Trypanosoma cruzi | 4 |
| 17439202 | 10.1021/jm0612867 | NON-PROTEIN TARGET | 4 |
| 28649316 | 10.1039/C6MD00573J | Protein arginine N-methyltransferase 1 | 4 |
| 9438029 | 10.1021/jm970570i | Rattus norvegicus | 3 |
| 9438029 | 10.1021/jm970570i | ADMET | 3 |
| 17517831 | 10.1128/aac.00005-07 | Trypanosoma brucei brucei | 3 |
| 18086841 | 10.1128/aac.00642-07 | ADMET | 3 |
| 21194955 | 10.1016/j.bmc.2010.11.047 | Trypanosoma brucei rhodesiense | 3 |
Data from ChEMBL 36 via Core Engine