Assay Detail
Functional
CHEMBL1055850
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.57 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249456 | — | — | 1 | 8.68 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.55 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.49 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.19 |
| CHEMBL365916 | — | — | 1 | 7.68 |
| CHEMBL563466 | — | — | 1 | 7.33 |
| CHEMBL563138 | — | — | 1 | 7.33 |
| CHEMBL563040 | — | — | 1 | 7.17 |
| CHEMBL560542 | — | — | 1 | 7.13 |
| CHEMBL561886 | — | — | 1 | 7.11 |
| CHEMBL556238 | — | — | 1 | 6.85 |
| CHEMBL557669 | — | — | 1 | 6.84 |
| CHEMBL181480 | — | — | 1 | 6.84 |
| CHEMBL549590 | — | — | 1 | 6.79 |
| CHEMBL549861 | — | — | 1 | 6.74 |
| CHEMBL549306 | — | — | 1 | 6.66 |
| CHEMBL563278 | — | — | 1 | 6.65 |
| CHEMBL551343 | — | — | 1 | 6.63 |
| CHEMBL556926 | — | — | 1 | 6.60 |
| CHEMBL559883 | — | — | 1 | 6.53 |
| CHEMBL560083 | — | — | 1 | 6.51 |
| CHEMBL564728 | — | — | 1 | 6.50 |
| CHEMBL563240 | — | — | 1 | 6.49 |
| CHEMBL550609 | — | — | 1 | 6.46 |
| CHEMBL549382 | — | — | 1 | 6.45 |
| CHEMBL556511 | — | — | 1 | 6.42 |
| CHEMBL560540 | — | — | 1 | 6.19 |
| CHEMBL563219 | — | — | 1 | 6.09 |
| CHEMBL558138 | — | — | 1 | 6.02 |
| CHEMBL564393 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249456 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL365916 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL563466 | — | IC50 | = | 46.2 | nM | 7.33 |
| CHEMBL563138 | — | IC50 | = | 47.3 | nM | 7.33 |
| CHEMBL563040 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL560542 | — | IC50 | = | 74.8 | nM | 7.13 |
| CHEMBL561886 | — | IC50 | = | 77.8 | nM | 7.11 |
| CHEMBL556238 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL557669 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL181480 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL549590 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL549861 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL549306 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL563278 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL551343 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL556926 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL559883 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL560083 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL564728 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL563240 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL550609 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL549382 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL556511 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL560540 | — | IC50 | = | 647.0 | nM | 6.19 |
| CHEMBL563219 | — | IC50 | = | 812.0 | nM | 6.09 |
| CHEMBL558138 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL564393 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL562402 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL564717 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL551342 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL563894 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL557938 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL559255 | — | IC50 | = | 7710.0 | nM | 5.11 |
| CHEMBL557734 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL556441 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL560143 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL559326 | — | IC50 | > | 62600.0 | nM | - |