Assay Detail
Functional
CHEMBL939424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiprotozoan activity against Trypanosoma brucei rhodesiense STIB900
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.12 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.37 |
| CHEMBL145251 | — | — | 1 | 8.19 |
| CHEMBL405915 | — | — | 1 | 8.12 |
| CHEMBL407410 | — | — | 1 | 7.89 |
| CHEMBL259792 | — | — | 1 | 7.85 |
| CHEMBL259707 | — | — | 1 | 7.82 |
| CHEMBL261271 | — | — | 1 | 7.42 |
| CHEMBL259591 | — | — | 1 | 6.08 |
| CHEMBL259825 | — | — | 1 | 5.76 |
| CHEMBL261059 | — | — | 1 | 5.63 |
| CHEMBL259500 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24057 | FURAMIDINE | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL145251 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL405915 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL407410 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL259792 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL259707 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL261271 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL259591 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL259825 | — | IC50 | = | 1739.0 | nM | 5.76 |
| CHEMBL261059 | — | IC50 | = | 2367.0 | nM | 5.63 |
| CHEMBL259500 | — | IC50 | = | 7207.0 | nM | 5.14 |